Hippocampus Function
Hippocampus Function: What Does It Do? Structure Of The Hippocampal Formation. The hippocampal formation is located within. Functions Of The Hippocampus. The hippocampus surrounded by other structures. Damage Of The Hippocampus. The hippocampus surrounded by the various gyri and horns. Learning a new language or challenging one’s brain by learning new facts is yet another way to grow the very part of your brain that is critical for our ability to keep your memories alive for a lifetime and stay sharp as we get older. Unfortunately, hippocampus can shrink as easily as it can grow.
The hippocampus, Latin for seahorse, is named for its shape. It is part of a system that directs many bodily functions: the limbic system. This system is located in the brain's medial temporal lobe, near the center of the brain.
The hippocampus is involved in the storage of long-term memory, which includes all past knowledge and experiences. Scientists are unsure exactly how this occurs. In particular, the hippocampus seems to play a major role in declarative memory, the type of memory involving things that can be purposely recalled, such as facts or events.
The hippocampus is not involved with short-term memory and procedural memory types (memory of how to do motor actions, like walking). These are primarily handled by the cortex and the cerebellum.
Those that have lost function or had removed major portions of the limbic system but still have the hippocampus, have only long-term memory and cannot record any new memories or functions.
- For the small fish, go to seahorse
| Hippocampus | |
|---|---|
The hippocampus is located in the medial temporal lobe of the brain. In this lateral view of the human brain, the frontal lobe is at the left, the occipital lobe at the right, and the temporal and parietal lobes have largely been removed to reveal the hippocampus underneath. | |
Hippocampus (lowest pink bulb) as part of the limbic system | |
| Details | |
| Part of | Temporal lobe |
| Identifiers | |
| Latin | Hippocampus |
| MeSH | D006624 |
| NeuroLex ID | birnlex_721 |
| TA | A14.1.09.321 |
| FMA | 275020 |
| Anatomical terms of neuroanatomy | |
The hippocampus is part of the mammalianbrain, and belongs to the limbic system. Humans and other mammals have two, one in each side of the brain. The hippocampus is under the cerebral cortex.[1]It is important in spatial memory and navigation, and helps turn short-term memory into long-term memory. The hippocampus is named after the seahorse because its shape is similar.
In Alzheimer's disease, the hippocampus is one of the first regions of the brain to suffer damage; memory loss and disorientation are included among the early symptoms. People with extensive, bilateral hippocampal damage may experience anterograde amnesia – the inability to form or retain new memories.
The different neuronal cell types are neatly organized into layers in the hippocampus. It has often been used as a model system for studying neurophysiology. Long-term potentiation (LTP), a neural mechanism for storing memory, was first discovered to occur in the hippocampus.
Hippocampus and memory[changechange source]
The connection of hippocampus with memory was made by a famous report.[2] This gave the results of the destruction of the hippocampi by surgery (an attempt to relieve epileptic seizures).[3] The unexpected outcome of the surgery was severe anterograde and partial retrograde amnesia. The patient could not form new memories of events after his surgery, and could not remember any events that occurred just before his surgery. However, he did remember events from many years earlier, right back to his childhood.
This case attracted widespread professional interest.[4] Later, other patients with similar damage and amnesia (caused by accident or disease) have also been studied. Thousands of experiments have studied the physiology of changes in synaptic connections in the hippocampus after activity. The hippocampi do play an important role in memory. However, the precise nature of this role remains unclear.[5][6]
Recent reviews say how the hippocampus puts together our memories of past events, and helps us remember aspects of complex events.[7][8]
Hippocampus and orientation[changechange source]
Neurons in the rat hippocampus show activity related to the rat's position in its environment.[9][10] As with the memory theory, there is now almost universal agreement that spatial coding plays an important role in hippocampal function, but the details are widely debated.[11]
Studies conducted on freely moving rats and mice have shown that many hippocampal neurons have 'place fields', that is, they fire bursts of action potentials when a rat passes through a particular part of the environment. In humans, cells with location-specific firing patterns have been reported in a study. Patients with drug-resistant epilepsy had diagnostic electrodes put in their hippocampus. Then a computer was used to move them around in a virtual reality town.[12]
The discovery of place cells in the 1970s led to a theory that the hippocampus might act as a cognitive map –a neural representation of the layout of the environment.[10] The 'cognitive map hypothesis' has been further advanced by recent discoveries of direction cells in several parts of the rodent brain which are strongly connected to the hippocampus.[11][13]
Evolution[changechange source]
The hippocampus has a generally similar appearance across the mammals from monotremes such as the echidna to primates such as humans.[14] The hippocampal size to body-size ratio increases: it is about twice as large for primates as for the echidna. It does not, however, increase at anywhere close to the rate of the neocortex to body-size ratio. Therefore, the hippocampus takes up a larger fraction of the cortex in rodents than in primates.
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Other vertebrates have areas which may be homologous to the hippocampus of mammals.[15] Some insects, and cephalopods such as the octopus, have strong spatial learning and navigation abilities. These appear to work differently from the mammalian spatial system, and have evolved independently of the mammalian system.
References[changechange source]
- ↑http://neuroscience.uth.tmc.edu/s4/chapter05.html
- ↑Scoville W.B. & Milner B. 1957. Loss of recent memory after bilateral hippocampal lesions. J. Neurol. Neurosurg. Psych. 20 (1): 11–21. [1]
- ↑N.Y. Times, 12-06-2008
- ↑Squire L.R. 2009. The legacy of patient H.M. for neuroscience. Neuron61 (1): 6–9. [2]
- ↑Squire L.R. 1992. Memory and the hippocampus: a synthesis from findings with rats, monkeys, and humans. Psych. Rev. 99 (2): 195–231. [3]
- ↑Eichenbaum H. & Cohen N.J. 1993. Memory, amnesia, and the hippocampal system. MIT Press.
- ↑Webb, Jonathan 2015. Peeking into the brain's filing system. BBC News Science & Environment. [4]
- ↑Horner, Adrian J et al 2015. Evidence for holistic episodic recollection via hippocampal pattern completion. Nature Communications6, article number 7462. [5]
- ↑O'Keefe J. & Dostrovsky J. 1971. The hippocampus as a spatial map. Preliminary evidence from unit activity in the freely-moving rat. Brain Res34 (1): 171–75. [6]
- ↑ 10.010.1O'Keefe J. & Nadel L. 1978. The hippocampus as a cognitive map. Oxford University Press.
- ↑ 11.011.1Moser E.I; Kropf E. & Moser M-B. 2008. Place cells, grid cells, and the brain's spatial representation system. Ann. Rev. Neurosci. 31: 69 [7]
- ↑Ekstrom A.D. et al 2003. Cellular networks underlying human spatial navigation. Nature425 (6954): 184–88. [8]
- ↑Solstad T. et al 2008. Representation of geometric borders in the entorhinal cortex. Science322 (5909): 1865–68. [9]
- ↑West M.J. 1990. Stereological studies of the hippocampus: a comparison of the hippocampal subdivisions of diverse species including hedgehogs, laboratory rodents, wild mice and men. Prog. Brain Res. 83: 13–36. [10]
- ↑Rodríguez F. et al 2002. Spatial memory and hippocampal pallium through vertebrate evolution: insights from reptiles and teleost fish. Brain Res. Bull. 57 (3–4): 499–503. [11]